Kimiko Krieger

Research Overview

The Krieger Lab studies the intersectionality of metabolism and DNA damage in African American men with prostate cancer and how metabolic pathway rewiring supports defects in DNA repair. DNA damage repair pathways are critical for maintaining genome stability and preventing the accumulation of damage leading to tumorigenesis. Nucleotide metabolism pathways are critical rate-limiting processes for DNA repair capacity as they support DNA repair by maintaining nucleotide pools necessary to repair single-strand and double-strand breaks. 

Our laboratory will use multi-omics, spatial, and molecular biological approaches to target novel vulnerabilities in DNA damage repair and nucleotide metabolism pathways. Elucidating the intersection of these pathways will improve our understanding of cancer susceptibilities in African American men and tailor chemotherapeutic strategies.